Medical Fiber Optics for PDT

Our CE-marked cylindrical diffusers emit light radially and uniformly along a diffusing length of 5 to 90 mm. They are intended for illumination in phototherapies in head & neck, esophagus, lung, bile duct, pancreas and urology.

They are compatible with all major PDT lasers and standard endoscopes and are available with X-ray markers for CT visibility. Three models cover access from a 20G catheter to 4 Fr working channels: CD-2S3, CD-403 and CD-4L3.

Developed and manufactured in Bonn under a quality management system certified to ISO 13485 and EU MDR (2017/745).

Cylindrical diffuser fiber held between fingers
Blue, green and red fiber optic illumination for biomedical research

Fiber Optics for Biomedical Labs

For research laboratories we supply cylindrical diffusers that deliver light uniformly into tissue, cultures and other volumes, from 400 to 860 nm.

The ultra-thin CD-2XS2 (~450 µm, fits through a 22G cannula) is made for small targets in preclinical PDT, optogenetics and photobiology. It is MR-compatible, so it can also be used inside NMR spectrometers and MRI scanners.

For antimicrobial light, biofilm models and photobioreactors, our diffusers illuminate liquids, tubes and vessels from inside.

Custom lengths, wavelengths and connectors on request. Contact our technical team.

Support for Clinical Studies

We support clinical studies of light-based therapies in Europe and the United States, from site evaluation, ethics committee applications and study documentation (protocols, synopses, manuals) to on-site technical support and project management. Our experience covers oncology, urology, phlebology, dentistry and photodynamic therapy.

LifePhotonic diffusers have been or are being used as light applicators in registered clinical studies, including:

  • NOA11: stereotactic interstitial PDT with 5-ALA in recurrent glioblastoma, Universitätsklinikum Münster (EudraCT 2015-002727-25, NCT04469699)
  • GL01: stereotactic interstitial PDT with PD L 506 in newly diagnosed glioblastoma, photonamic (NCT03897491)
  • ENLIGHTED: phase 3, padeliporfin vascular-targeted photodynamic therapy (VTP) of low-grade upper tract urothelial cancer, Steba Biotech; sites in the US, Europe and Israel (NCT04620239, study website)
Two surgeons holding diffusor fibers
Clinician in the operating room holding a fiber optic

Development & Certification

We support manufacturers through medical device development and certification: CE marking under the EU MDR (2017/745), FDA 510(k) submissions, ISO 13485 quality management systems and risk management to ISO 14971, including clinical evaluation. Smaller companies can engage us as their quality management representative.

Our development focus is on medical lasers, fiber optics and their clinical application, from the first concept to the certified product.